USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P09936 USC-OGP 2-DE database:  P09936 P09936 General information about the entry View entry in simple text format Entry name UCHL1_HUMAN Primary accession number P09936 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin carboxyl-terminal hydrolase isozyme L1; Short=UCH-L1; EC=3.4.19.12; EC=6.-.-.-; AltName: Full=Neuron cytoplasmic protein 9.5; AltName: Full=PGP 9.5; Short=PGP9.5; AltName: Full=Ubiquitin thioesterase L1; Flags: Precursor;. Gene name Name=UCHL1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1279: pI=5.65; Mw=26938 SPOT OGP-1280: pI=5.93; Mw=26725 SPOT OGP-1283: pI=5.35; Mw=25790 SPOT OGP-1285: pI=5.42; Mw=25688 SPOT OGP-1286: pI=6.01; Mw=25688 SPOT OGP-1287: pI=6.52; Mw=25485 Cross-references UniProtKB/Swiss-Prot P09936; UCHL1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UCHL1_HUMAN Primary accession number P09936 Secondary accession number(s) Q4W5K6 Q71UM0 Sequence was last modified on  November 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 194) Name and origin of the protein Description RecName: Full=Ubiquitin carboxyl-terminal hydrolase isozyme L1; Short=UCH-L1; EC=3.4.19.12; EC=6.-.-.-; AltName: Full=Neuron cytoplasmic protein 9.5; AltName: Full=PGP 9.5; Short=PGP9.5; AltName: Full=Ubiquitin thioesterase L1; Flags: Precursor; Gene name Name=UCHL1 Encoded on Name=UCHL1 Keywords 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Glycoprotein; Hydrolase; Ligase; Lipoprotein; Membrane; Neurodegeneration; Oxidation; Parkinson disease; Parkinsonism; Phosphoprotein; Polymorphism; Prenylation; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AC095043; AAY40923.1; -; Genomic_DNA EMBL CH471069; EAW92983.1; -; Genomic_DNA EMBL BC000332; AAH00332.1; -; mRNA EMBL BC005117; AAH05117.1; -; mRNA EMBL BC006305; AAH06305.1; -; mRNA EMBL X17377; CAA35249.1; -; Genomic_DNA EMBL X04741; CAA28443.1; ALT_INIT; mRNA EMBL AH007277; AAD09172.1; -; Genomic_DNA CCDS CCDS3462.1; -; . PIR A25856; A25856; . RefSeq NP_004172.2; NM_004181.4; . UniGene Hs.518731; -; . PDB 2ETL; X-ray; 2.40 A; A/B=1-223 PDB 2LEN; NMR; -; A=1-223 PDB 3IFW; X-ray; 2.40 A; A=1-223 PDB 3IRT; X-ray; 2.80 A; A/B=1-223 PDB 3KVF; X-ray; 2.80 A; A=1-223 PDB 3KW5; X-ray; 2.83 A; A=1-223 PDB 4DM9; X-ray; 2.35 A; A/B=1-223 PDB 4JKJ; X-ray; 2.15 A; A/B=1-223 PDBsum 2ETL; -; . PDBsum 2LEN; -; . PDBsum 3IFW; -; . PDBsum 3IRT; -; . PDBsum 3KVF; -; . PDBsum 3KW5; -; . PDBsum 4DM9; -; . PDBsum 4JKJ; -; . ProteinModelPortal P09936; -; . SMR P09936; -; . BioGrid 113192; 53; . DIP DIP-36620N; -; . IntAct P09936; 22; . MINT MINT-1378022; -; . STRING 9606.ENSP00000284440; -; . BindingDB P09936; -; . ChEMBL CHEMBL6159; -; . GuidetoPHARMACOLOGY 2426; -; . MEROPS C12.001; -; . iPTMnet P09936; -; . PhosphoSitePlus P09936; -; . SwissPalm P09936; -; . BioMuta UCHL1; -; . DMDM 136681; -; . DOSAC-COBS-2DPAGE P09936; -; . UCD-2DPAGE P09936; -; . EPD P09936; -; . PaxDb P09936; -; . PeptideAtlas P09936; -; . PRIDE P09936; -; . TopDownProteomics P09936; -; . DNASU 7345; -; . Ensembl ENST00000284440; ENSP00000284440; ENSG00000154277; . Ensembl ENST00000503431; ENSP00000422542; ENSG00000154277; . GeneID 7345; -; . KEGG hsa:7345; -; . CTD 7345; -; . DisGeNET 7345; -; . GeneCards UCHL1; -; . GeneReviews UCHL1; -; . HGNC HGNC:12513; UCHL1; . HPA CAB002580; -; . HPA HPA005993; -; . MalaCards UCHL1; -; . MIM 191342; gene; . MIM 613643; phenotype; . MIM 615491; phenotype; . neXtProt NX_P09936; -; . OpenTargets ENSG00000154277; -; . Orphanet 352654; Early-onset progressive neurodegeneration - blindness - ataxia - spasticity; . Orphanet 2828; Young adult-onset Parkinsonism; . PharmGKB PA37160; -; . eggNOG KOG1415; Eukaryota; . eggNOG ENOG4111HNA; LUCA; . GeneTree ENSGT00510000046640; -; . HOGENOM HOG000182400; -; . HOVERGEN HBG075483; -; . InParanoid P09936; -; . KO K05611; -; . PhylomeDB P09936; -; . TreeFam TF316166; -; . BRENDA 3.4.19.12; 2681; . Reactome R-HSA-5689603; UCH proteinases; . SABIO-RK P09936; -; . SIGNOR P09936; -; . ChiTaRS UCHL1; human; . EvolutionaryTrace P09936; -; . GeneWiki Ubiquitin_carboxy-terminal_hydrolase_L1; -; . GenomeRNAi 7345; -; . PRO PR:P09936; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000154277; -; . CleanEx HS_UCHL1; -; . ExpressionAtlas P09936; baseline and differential; . Genevisible P09936; HS; . GO GO:1904115; C:axon cytoplasm; IEA:GOC; . GO GO:0005737; C:cytoplasm; ISS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0044306; C:neuron projection terminus; IEA:Ensembl; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0031694; F:alpha-2A adrenergic receptor binding; IPI:BHF-UCL; . GO GO:0004197; F:cysteine-type endopeptidase activity; IDA:UniProtKB; . GO GO:0016874; F:ligase activity; IEA:UniProtKB-KW; . GO GO:0008242; F:omega peptidase activity; IDA:UniProtKB; . GO GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IBA:GO_Central; . GO GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; TAS:Reactome; . GO GO:0043130; F:ubiquitin binding; IDA:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0007628; P:adult walking behavior; IEA:Ensembl; . GO GO:0007412; P:axon target recognition; IEA:Ensembl; . GO GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl; . GO GO:0008283; P:cell proliferation; IEA:Ensembl; . GO GO:0042755; P:eating behavior; IEA:Ensembl; . GO GO:0048747; P:muscle fiber development; IEA:Ensembl; . GO GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL; . GO GO:0050905; P:neuromuscular process; IEA:Ensembl; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; NAS:ParkinsonsUK-UCL; . GO GO:0016579; P:protein deubiquitination; IDA:UniProtKB; . GO GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL; . GO GO:0002931; P:response to ischemia; IEA:Ensembl; . GO GO:0019233; P:sensory perception of pain; IEA:Ensembl; . Gene3D 3.40.532.10; -; 1; . InterPro IPR001578; Peptidase_C12_UCH; . InterPro IPR030297; UCHL1; . PANTHER PTHR10589; PTHR10589; 1; . PANTHER PTHR10589:SF33; PTHR10589:SF33; 1; . Pfam PF01088; Peptidase_C12; 1; . PRINTS PR00707; UBCTHYDRLASE; . PROSITE PS00140; UCH_1; 1; .

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